The exact mechanism of action of S-23 is still not so clear. In animal research, S23 displayed a good ratio of anabolic to androgenic effects as well as dose-dependent restraint of spermatogenesis (the course of sperm cell development) with unprompted recuperation after end of treatment.
S-23 is an orally active nonsteroidal SARM with high binding affinity to androgen receptors that appears to increase muscle mass, decrease fat mass, decrease prostate size, and act as an effective and reversible hormonal male contraceptive in rats.
Data shows that a dose of 0.3 mg S23 [human equivalent: 15 mg] leads to an increase in muscle mass, but that the prostate dimensions decreased. S23 not only boosted muscle mass, but also reduced fat mass.
S23 halts the production of sperm in the testes. In fact it does this so well that the researchers suspect S23 might be a good candidate for a male contraceptive.
Researchers found that treating non-castrated male rats for 14 days with 0.1mg/day or more of this compound, decreased LH levels by 50+%, significantly decreased prostate size, and significantly increased levator ani muscle size. Although the increased muscle growth is a positive sign, the decreased LH levels and prostate size is a big red flag.
S-23 was also found to increase BMD, and reduce fat mass in lab rats. S23 is particularly unique because of its potential as a contraceptive. When non-castrated male rats were treated with 0.1mg/d of S-23 and EB for 10 weeks, LH and FSH levels decreased, 4 of the 6 male rats had no sperm in the testis, and none of the six rat couples experienced pregnancies during mating trials.
S-23 SIDE EFFECTS
How safe is S23? Many researchers want to know S-23’s safety before any action is made. Most of these SARMs have not yet been tested on humans, but only on rats or mice. This is also true for S23.
S23 can be found in some webstores that sell research chemicals online. Not much is known about the working or side effects of SARMs in human. And a 2009 animal study, in which researchers at GTx tried S23 out on rats, suggests that S23 is a little more risky than other SARMS.
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