S-4 (Andarine) is the most investigated and researched SARM so far. It is also the most versatile SARM ever created. Like most SARMs, the primary purpose of S-4 aimed to develop an alternative treatment to age-related muscle wasting, osteoporosis, and similar symptoms of hypogonadism, or end-stage renal disease.
S-4 started out as a new development for male contraceptives and showed some promising effects. There had been decreases in spermatogenesis and an increase in male libido. One study in particular compared S-4 to DHT (a common anabolic steroid); the results have shown that S-4 exceeded DHT in producing lean muscle mass over the course of 120 days with only 3mg per day. S-4 has also shown no side effects on prostate growth, testosterone shut down, or any negative side effects caused by traditional anabolic steroids [Kearbey et al., 2007]. Another study identified that S-4 is completely absorbed even at very low doses. The half-life for S-4 is between 2.6 to 5.3 hours.
HowAndarine/S4 (Powder form) works?
S4 is a SARM with utmost androgenic effects as it around 33% of the strength of testosterone when attaching to AR. S-4 also increases the amount of muscle mass produced by desensitizing the AR to the individual’s natural testosterone to influence a stronger effect.
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